What is your microbiome?

What is your microbiome?

Hey guys, I’m sure you have heard the term microbiome by now as well as genome and sure the microbiome has to do with human microbes genes and genome with our human genes but what does that really mean to us as a regular person who is not a scientist or doctor?

The best definition as well as simplest definition that I have found comes from learn.genetics.utah.edu which states “Some use “microbiome” to mean all the microbes in a community. We and others use it to mean the full collection of genes of all the microbes in a community. The human microbiome (all of our microbes’ genes) can be considered a counterpart to the human genome (all of our genes). The genes in our microbiome outnumber the genes in our genome by about 100 to 1. Microbes are everywhere: in the soil, in the water, and even in our bodies. That's right! Microbes cover every surface of our bodies, both inside and out. These microscopic life forms represent thousands of species, and they outnumber our own cells by about 10 to 1. A few microbes cause disease, but most do not. In fact, many are essential for good health.”

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So what is Zonulin all about?

So what is Zonulin all about?

Hey guys, I was watching a medical talk last week and the doctor was discussing how leaky gut is becoming more prevalent in our society. It is leading to many challenges for patients and that this is new to doctors because although scientists have made several breakthroughs in identifying molecules like zonulin there is much to be learned. It was more than half-way through his talk, that the doctor realized he needed to back-track a bit because many of the doctors in the room were unaware of how zonulin works and I thought wow. Sure I’ve heard of zonulin and understand the basics but it is quite complex so that inspired me to locate an older article explaining some of the basics of zonulin and over the next few months we’ll dive in deeper so that we all have a better understanding how to heal our bodies.

Some may ask why leaky gut is important to understand if you have celiac disease or are non-celiac gluten sensitivity and the truth is for celiacs it is a common complication and health issue that comes up when your body is not healing properly.

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Gluten-free diet simply works!

Gluten-free diet simply works!

Hey guys, this weeks article they present an 18 year old male with Selective IgM deficiency (sIGMD, which is quite rare found in approximately 5% of celiac disease patients) masking seronegative celiac disease (seronegative is where some celiac patients antibodies are negative). His symptoms included abdominal pain, diarrhea and weight loss which had been present for a year. Laboratory tests showed reduced IgM, DQ2-HLA and negative anti-transglutaminase. Villous atrophy and diffuse immature lymphocytes (lymphocrytes are one subset of white cells and they are the main type of cell found in lymph) were observed at histology. Tissue transglutaminase mRNA mucosal levels showed a 6-fold increase. The course of treatment was a gluten-free diet

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    Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity

    Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity

    Hey guys, this weeks article is an important one because it shows that both hybrid strains and ancient stains of wheat are toxic to not only those with celiac disease but to those with non-celiac gluten sensitivity as well. Here are some direct points the article made:

    • Increased intestinal permeability after gliadin exposure occurs in all individuals. Following gliadin exposure, both patients with gluten sensitivity and those with active celiac disease demonstrate a greater increase in intestinal permeability than celiacs in disease remission. A higher concentration of IL-10 was measured in the media exposed to control explants compared to celiac disease in remission or gluten sensitivity.
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    Non-Celiac Gluten Sensitivity Triggers Gut Dysbiosis, Neuroinflammation, Gut-Brain Axis Dysfunction, and Vulnerability for Dementia

    Non-Celiac Gluten Sensitivity Triggers Gut Dysbiosis, Neuroinflammation, Gut-Brain Axis Dysfunction, and Vulnerability for Dementia

    Hey guys, interesting that non-celiac gluten sensitivity and the inflammation in our gut microbiota can lead to dysfunction and systemic inflammation in our bodies however these authors believe that there could be therapeutic measures that can be done to prevent our vulnerability to Alzheimer’s disease and cognitive dysfunction.

    • The non-celiac gluten sensitivity (NCGS) is a chronic functional gastrointestinal disorder which is very common worldwide. The human gut harbors microbiota which has a wide variety of microbial organisms; they are mainly symbiotic and important for well being. 
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    The Immunology of Gluten Sensitivity Beyond The Intestinal Tract

    The Immunology of Gluten Sensitivity Beyond The Intestinal Tract

    Hey guys, found this article and honestly I could have listed everything here as it discusses the many links with so many different diseases from myocarditis, rheumatoid arthritis, osteoporosis, osteopenia, gluten ataxia, type 1 diabetes, etc so I highly recommend you read this article and I’ve chosen a few points that stood out to me.

    • During the past five years, based on overwhelming evidence of immune pathogenesis involving organs other than gut and skin, many scientists have begun to re-evaluate the notion that gluten sensitivity is solely a disease of the gut. Other organs suspected of involvement include: the joints, the heart, thyroid, bone, the brain cerebellum and the neuronal synapsins.
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    Differential Mucosal IL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Celiac Disease

    Differential Mucosal IL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Celiac Disease

    Hey guys, this article is what is considered a landmark article because it has specifically identified the difference between celiac disease and gluten sensitivity and how specifically how our body responds when digesting gluten.

    • Gluten is the trigger of a heterogeneous set of conditions, including wheat allergy, gluten sensitivity (GS), and celiac disease (CD), that, combined, affect about 10% of the general population.
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    Increased Risk for Vitamin D Deficiency in Obese Children with Both Celiac Disease and Type 1 Diabetes

    Increased Risk for Vitamin D Deficiency in Obese Children with Both Celiac Disease and Type 1 Diabetes

    Hey guys, I think this article certainly brings up an interesting question as to could vitamin D deficiency be a contributing factor in obesity in kids with celiac disease and type 1 diabetes. Additional research will be needed to confirm their findings and here are a few of the key points.

    • There is considerable clinical and pathogenic overlap between type 1 diabetes (T1D) and celiac disease (CD). These two autoimmune diseases have similar genetic background and trigger mechanisms . The common genetic basis for the expression of both diseases derives from the identification of human leucocyte antigen (HLA) class II molecules, DQ8 and DQ2 as key genetic risk factors for T1D and CD the United States .
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    Migraine Associated with Gastrointestinal Disorders: Review of the Literature and Clinical Implications

    Migraine Associated with Gastrointestinal Disorders: Review of the Literature and Clinical Implications

    Hey guys, when I think of migraines, I just think of a tremendous amount of pain. Headaches were always something of an issue for me as a child and then I made the leap to official migraines in my early twenties and talk about debilitating and ouchy. Yes there are tons of medication out there for migraines; however lucky for me I only had four to six monsters a year, my then neurologist suggested I take medication 365 days a year to prevent them and that just wasn’t me, so I had to find alternative means to deal with them. One way was to steer clear of certain foods that would trigger headaches like dairy, processed meats and chocolate… don’t remember wheat, barley or rye ever being on any of those lists. How about you? 

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    Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders

    Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders

    Hey guys, to be honest when I read this article, it certainly put a damper on the landmark article from a few weeks ago that I wrote about that was roughly three years prior that there still continues to be so much debate going on as to the validity of non-celiac gluten sensitivity as an issue.

    • Gluten sensitivity (GS) was originally described in the 1980sand a recently “re-discovered” syndrome entity, characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA).
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