Effect of Gliadin on Permeability of Intestinal Biopsy Explants from Celiac Disease Patients and Patients with Non-Celiac Gluten Sensitivity

Justin Hollon, Elaine Leonard Puppa, Bruce Greenwald, Eric Goldberg, Anthony Guerrerioand Alessio Fasano

Nutrients 2015, 7, 1565-1576; doi:10.3390/nu7031565


Hey guys, this weeks article is an important one because it shows that both hybrid strains and ancient stains of wheat are toxic to not only those with celiac disease but to those with non-celiac gluten sensitivity as well. Here are some direct points the article made:

  • Increased intestinal permeability after gliadin exposure occurs in all individuals. Following gliadin exposure, both patients with gluten sensitivity and those with active celiac disease demonstrate a greater increase in intestinal permeability than celiacs in disease remission. A higher concentration of IL-10 was measured in the media exposed to control explants compared to celiac disease in remission or gluten sensitivity.
  • Along with the increasing awareness of CD has come the emerging recognition that there are individuals who clinically react to gluten-containing food ingestion without demonstration of T-cell mediated process in the gastrointestinal mucosa. These individuals are classified as having non-celiac gluten sensitivity (GS)
  • While the symptoms of GS may mirror that of CD, and these symptoms may resolve on a GFD, these individuals have no histologic evidence of small intestine enteropathy while on a gluten- containing diet.
  • GS carries no association with an elevated tTG antibodies, although several studies have shown a higher frequency of positive anti-gliadin antibodies (AGA) then the general population.
  • The apparent lack of adaptive immune activation in GS raises the hypothesis that the similarities between GS and CD may be more related to a common defect in the intestinal barrier function.
  • The study was aimed to determine whether gliadin causes a similar effect in non-celiac subjects by exposing, to gliadin, internal biopsy explants from four different study groups: celiac patients with active disease (ACD), celiac patients in remission (RCD), non-celiac patients with gluten sensitivity (GS) and non-celiac controls (NC). 
  • They found that enhanced intestinal permeability upon gliadin exposure does not appear to be limited to CD patients. Gliadin exposure induces an increased intestinal permeability in all individuals, regardless of whether or not they have celiac disease. The results of this study suggest that gluten exposure leads to altered barrier function in ACD and GS, resulting in exaggerated increase in intestinal permeability when compared to RCD.

This article is extremely important for all those who do not have celiac disease but for those of you that have non-celiac gluten sensitivity to understand that your body is having a reaction to gliadin exposure and it is effecting your gut (intestinal permeability) and perhaps its time take your health, your diet and your body more seriously.

I can’t tell you, how many people I know who know their body functions better when they are off gluten; however, they think they can manage their symptoms, or they think its too difficult to cut out gluten completely from their life when in truth they are missing the bigger and whole picture. And that would be the more they continue to eat things that are harmful to their health on a continual basis the more complications they will continue to have with their health that they believe are unrelated but truly have no clue that what happens in your gut, will determine your health and your quality of life.

According to the New England Journal of Medicine it takes roughly eight to ten years for a patient to be diagnosed with celiac disease after multiple visits and multiple doctors when seeking treatment. Non-celiac gluten sensitivity is an extremely new diagnosis that many doctors have not even agreed with let alone have a set course of action for a patient to follow. Many non-celiac gluten sensitivity patients have no clue how serious this can be for their health and are left searching for answers. This is where I hope I can help shed some light and to give you some assistance creating a new, happier and better life for yourself and loved ones.

* Here’s my little disclaimer, I’m not a doctor, researcher, immunologist, just someone deeply concerned and trying to help as many peeps as I can make conscious, good, healthy choices for their health and their bodies when living life with gluten challenges. I have not been compensated or obligated to write this article, and as always, all thoughts and opinions are honest and my own!