Non-Celiac Gluten Sensitivity Triggers Gut Dysbiosis, Neuroinflammation, Gut-Brain Axis Dysfunction, and Vulnerability for Dementia

Daulatzai MA

CNS Neurol Disord Drug Targets. 2015 Feb 2.

Hey guys, interesting that non-celiac gluten sensitivity and the inflammation in our gut microbiota can lead to dysfunction and systemic inflammation in our bodies however these authors believe that there could be therapeutic measures that can be done to prevent our vulnerability to Alzheimer’s disease and cognitive dysfunction.

  • The non-celiac gluten sensitivity (NCGS) is a chronic functional gastrointestinal disorder which is very common worldwide. The human gut harbors microbiota which has a wide variety of microbial organisms; they are mainly symbiotic and important for well being. 
  • However, "dysbiosis" - i.e. an alteration in normal commensal gut microbiome with an increase in pathogenic microbes, impacts homeostasis/health. Dysbiosis in NCGS causes gut inflammation, diarrhea, constipation, visceral hypersensitivity, abdominal pain, dysfunctional metabolic state, and peripheral immune and neuro-immune communication. Thus, immune-mediated gut and extra-gut dysfunctions, due to gluten sensitivity with comorbid diarrhea, may last for decades.
  • Pathogenic gut microbiota is known to upregulate gut- and systemic inflammation (due to lipopolysaccharide from pathogenic bacteria and synthesis of pro-inflammatory cytokines); they enhance energy harvest, cause obesity, insulin resistance, and dysfunctional vago-vagal gut-brain axis. Conceivably, the above cascade of pathology may promote various pathophysiological mechanisms, neuroinflammation, and cognitive dysfunction. Hence, dysbiosis, gut inflammation, and chronic dyshomeostasis are of great clinical relevance
  • It is argued here that we need to be aware of NCGS and its chronic pathophysiological impact. Therapeutic measures including probiotics, vagus nerve stimulation, antioxidants, alpha 7 nicotinic receptor agonists, and corticotropin-releasing factor receptor 1 antagonist may ameliorate neuroinflammation and oxidative stress in NCGS; they may therefore, prevent cognitive dysfunction and vulnerability to Alzheimer's disease.

Is it me is this a pretty big article here? I am for anything that is going to keep my cognitive function in the later years in my life. 

I never really even considered what that would be really like until I had some serious episodes of brain fog and I’d find myself some place and no clue why I was there or what I wanted. 

Obviously, I am not comparing the two by any means, I’m just saying it certainly was a wake-up call, that reminded me that I very much need to be aware of the inflammation in my body and neuro-inflammation scares me. 

Cause if I loose my ability to make real and informed decisions for myself than I could be stuck waiting 17 years for this research that is produced in 2015 for my doctor down the street to put into practice in 2032 and that absolutely will not work for me. How about you?

Just something to think about and to consider when making food choices that could have a significant affect on your health and your future health as well as your families.

* Here’s my little disclaimer, I’m not a doctor, researcher, immunologist, just someone deeply concerned and trying to help as many peeps as I can make conscious, good, healthy choices for their health and their bodies when living life with gluten challenges. I have not been compensated or obligated to write this article, and as always, all thoughts and opinions are honest and my own!